6-Fluoronorepinefrin

6-Fluoronorepinefrin
(IUPAC) ime
	4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
Klinički podaci
Identifikatori
CAS broj	86820-21-5
ATC kod	nije dodeljen
PubChem	1862
ChemSpider	1792
ChEMBL	CHEMBL281232
Hemijski podaci
Formula	C8H10FNO3
Mol. masa	187.17 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2 ; Key: SBUQBFTXTZSRMH-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	nije kontrolisan

6-Fluoronorepinefrin (6-FNE) je selektivni puni agonist α₁- i α₂-adrenergičkih receptora, koji je srodan sa norepinefrinom.^[5]^[5]^[6] On je jedini poznati selektivni puni agonist α-adrenergičkih receptora. Bio je korišten u izučavanju funkcije tih receptora.^[6] Infuzija 6-FNE u locus coeruleus glodara proizvodi primetnu hiperaktivnost i disinhibiciju ponašanja.^[6]^[7]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). „Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines”. Journal of Medicinal Chemistry 22 (12): 1493–7. PMID 231654.
↑ ^6,0 ^6,1 ^6,2 Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). „Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist”. Brain Research 1291: 21–31. DOI:10.1016/j.brainres.2009.07.049. PMID 19632210.
↑ Stone EA, Grunewald GL, Lin Y, et al. (July 2003). „Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice”. Synapse (New York, N.Y.) 49 (1): 67–76. DOI:10.1002/syn.10212. PMID 12710017.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid231654-5] 5,0 ^5,1 Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). „Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines”. Journal of Medicinal Chemistry 22 (12): 1493–7. PMID 231654.

[pmid19632210-6] 6,0 ^6,1 ^6,2 Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). „Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist”. Brain Research 1291: 21–31. DOI:10.1016/j.brainres.2009.07.049. PMID 19632210.

[pmid12710017-7] Stone EA, Grunewald GL, Lin Y, et al. (July 2003). „Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice”. Synapse (New York, N.Y.) 49 (1): 67–76. DOI:10.1002/syn.10212. PMID 12710017.

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