(S)-norkoklaurinska sintaza
(S)-norkoklaurinska sintaza (EC 4.2.1.78, (S)-norlaudanozolinska sintaza, 4-hidroksifenilacetaldehidna hidrolijaza (dodaje dopamin)) je enzim sa sistematskim imenom 4-hidroksifenilacetaldehid hidrolijaza (dodaje dopamin, formira (S)-norkoklaurin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (S)-norkoklaurinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.78 | ||||||||
| CAS broj | 79122-01-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-hidroksifenilacetaldehid + dopamin (S)-norkoklaurin + H2O
Ovom reakcijom nastaje šestočlani prsten putem formiranja veze između C-6 sa 3,4-dihidroksifenilne grupe dopamina i C-1 aldehida u iminu formiranom između supstrata.
Reference
uredi- ↑ Stadler, R., Zenk, M.H. (1990). „A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline”. Liebigs Ann. Chem.: 555-562.
- ↑ Stadler, R., Kutchan, T.M., Zenk, M.H. (1989). „(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis”. Phytochemistry 28: 1083-1086.
- ↑ Samanani, N. and Facchini, P.J. (2002). „Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants”. J. Biol. Chem. 277: 33878-33883. PMID 12107162.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.