Valin dehidrogenaza (NAD+)
Valin dehidrogenaza (NAD+) (EC 1.4.1.23, valinska dehidrogenaza (NAD+)) je enzim sa sistematskim imenom L-valin:NAD+ oksidoreduktaza (deaminacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Valin dehidrogenaza (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.1.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-valin +H2O + NAD+ 3-metil-2-oksobutanoat + NH3 + NADH + H+
Ovaj enzim iz Streptomyces spp. nije aktivan sa NADP+, cf. EC 1.4.1.8, valin dehidrogenaza (NADP+).
Reference uredi
- ↑ Vancurová, I., Vancura, A., Volc, J., Neuzil, J., Flieger, M., Basarová, G. and Behal, V. (1988). „Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens”. J. Bacteriol. 170: 5192-5196. PMID 3182727.
- ↑ Navarrete, R.M., Vara, J.A. and Hutchinson, C.R. (1990). „Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2)”. J. Gen. Microbiol. 136: 273-281. PMID 2324704.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.