Triptofan 7-halogenaza
Triptofan 7-halogenaza (EC 1.14.14.7, PrnA, RebH) je enzim sa sistematskim imenom L-triptofan:FADH2 oksidoreduktaza (7-halogenacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Triptofan 7-halogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.14.7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- triptofan + FADH2 + Cl- + O2 + H+ 7-hloro-L-triptofan + FAD + 2H2O
Kod Lechevalieria aerocolonigenes ovaj enzim katalizuje inicijalni korak biosinteze rebekamicina.
Reference uredi
- ↑ Dong, C., Kotzsch, A., Dorward, M., van Pee, K.H. and Naismith, J.H. (2004). „Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens”. Acta Crystallogr. D Biol. Crystallogr. 60: 1438-1440. PMID 15272170.
- ↑ Yeh, E., Garneau, S. and Walsh, C.T. (2005). „Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis”. Proc. Natl. Acad. Sci. USA 102: 3960-3965. PMID 15743914.
- ↑ Bitto, E., Huang, Y., Bingman, C.A., Singh, S., Thorson, J.S. and Phillips Jr., G.N. (2008). „The structure of flavin-dependent tryptophan 7-halogenase RebH”. Proteins Struct. Funct. Genet. 70: 289-293.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.