Triptofan 2'-dioksigenaza
Triptofan 2'-dioksigenaza (EC 1.13.99.3, indol-3-alkan alfa-hidroksilaza, alfa,beta-oksidaza bočnog lanca triptofana, oksidaza II bočnog lanca triptofana, oksidaza bočnog lanca triptofana, TSO, indolil-3-alkan alfa-hidroksilaza, oksidaza tipa I bočnog lanca triptofana, TSO I, TSO II) je enzim sa sistematskim imenom L-triptofan:kiseonik 2'-oksidoreduktaza (odvajanje bočnog lanca).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Triptofan 2'-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.99.3 | ||||||||
| CAS broj | 64295-81-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-triptofan + O2 (indol-3-il)glikolaldehid + CO2 + NH3
Ovaj enzim je hemoprotein. On deluje na brojne indol-3-alkanske derivate, oksidujući 3-bočni-lanac u 2'-poziciji. Najbolji supstrati su L-triptofan i 5-hidroksi-L-triptofan.
Reference uredi
- ↑ Roberts, J. and Rosenfeld, H.J. (1977). „Isolation, crystallization, and properties of indolyl-3-alkane α-hydroxylase. A novel tryptophan-metabolizing enzyme”. J. Biol. Chem. 252: 2640-2647. PMID 15994.
- ↑ Takai, K., Ushiro, H., Noda, Y., Narumiya, S., Tokuyama, T. and Hayaishi, O. (1977). „Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives”. J. Biol. Chem. 252: 2648-2656. PMID 15995.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.