Ro10-5824 je lek koji deluje kao dopaminski agonist. On je selektivni parcijalni agonist D4 podtipa. Ro10-5824 deluje kao kognitivni pojačivač u životinjskim studijama.[3][4]
Ro10-5824
|
| (IUPAC) ime
|
| 2-metil-5-[(4-fenil-3,6-dihidro-2H-piridin-1-il)metil]pirimidin-4-amin
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| Klinički podaci
|
| Identifikatori
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| CAS broj
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189744-46-5
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| ATC kod
|
nije dodeljen
|
| PubChem[1][2]
|
16759175
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| Hemijski podaci
|
| Formula
|
C17H20N4
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| Mol. masa
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280,367 g/mol
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| SMILES
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eMolekuli & PubHem
|
| InChI |
|---|
InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20)  Y
Key: KABDATZAOUSYES-UHFFFAOYSA-N Y |
|
| Farmakoinformacioni podaci
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| Trudnoća
|
?
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| Pravni status
|
|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). „RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice”. Neuropharmacology 44 (4): 473–81. DOI:10.1016/S0028-3908(02)00412-4. PMID 12646284.
- ↑ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). „Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells”. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307. DOI:10.1017/S1461145707008061. PMID 17897483.
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