RYK kinaza
(Preusmjereno sa stranice RYK1)
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RYK kinaza (kinaza srodna sa receptorskom tirozinskom kinazom, RYK) je gen koji kodira protein Ryk.
| Tirozinska kinaza slična receptoru | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | RYK; D3S3195; JTK5; JTK5A; RYK1 | ||||||||||
| Vanjski ID | OMIM: 600524 MGI: 101766 HomoloGene: 68287 GeneCards: RYK Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6259 | 20187 | |||||||||
| Ensembl | ENSG00000163785 | ENSMUSG00000032547 | |||||||||
| UniProt | P34925 | Q01887 | |||||||||
| Ref. Sekv. (iRNK) | NM_001005861 | NM_001042607 | |||||||||
| Ref. Sekv. (protein) | NP_001005861 | NP_001036072 | |||||||||
| Lokacija (UCSC) | Chr 3: 133.78 - 133.97 Mb | Chr 9: 102.83 - 102.91 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj protein je atipični član familije receptorskih proteinskih tirozinskih kinaza faktora rasta. On se razlikuje od drugih članova po broju konzerviranih ostataka u aktivacionom i domenu vezivanja nukleotida. Ovaj genski produkt pripada podfamiliji čiji članovi nisu regulisani fosforilacijom u aktivacionom segmentu. Pretpostavlja se da se regulacija biološke aktivnosti odvija na do sada nerazjašnjem način. Poznate su dve alternativne splajsne varijante koje kodiraju distinktne izoforme.[1]
Struktura
urediPoput drugih receptorskih tirozinskih kinaza RYK se sastoji od tri domena, N-terminusnog ekstracelularnog ligand-vezujućeg domena, transmembranskog domena i C-terminusog intracelularnog domena. Međutim, za razliku od drugih receptorskih tirozinskih kinaza C-terminalni domen RYK ne manifestuje kinazno dejstvo.[2]
Reference
uredi- ↑ „Entrez Gene: RYK RYK receptor-like tyrosine kinase”.
- ↑ Halford, MM, and Stacker, S.A. (2001). „Revelations of the RYK receptor”. Bioessays 23 (1): 34–45. DOI:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307.
Literatura
uredi- Partanen J, Mäkelä TP, Alitalo R, et al. (1991). „Putative tyrosine kinases expressed in K-562 human leukemia cells.”. Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–8917. DOI:10.1073/pnas.87.22.8913. PMC 55070. PMID 2247464.
- Gough NM, Rakar S, Hovens CM, Wilks A (1995). „Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.”. Mamm. Genome 6 (4): 255–6. DOI:10.1007/BF00352411. PMID 7613029.
- Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.”. Oncogene 8 (12): 3403–3410. PMID 8247543.
- Stacker SA, Hovens CM, Vitali A, et al. (1993). „Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).”. Oncogene 8 (5): 1347–1356. PMID 8386829.
- Tamagnone L, Partanen J, Armstrong E, et al. (1993). „The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.”. Oncogene 8 (7): 2009–2014. PMID 8390040.
- Wang XC, Katso R, Butler R, et al. (1996). „H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.”. Mol. Med. 2 (2): 189–203. PMC 2230112. PMID 8726462.
- Katso RM, Russell RB, Ganesan TS (1999). „Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.”. Mol. Cell. Biol. 19 (9): 6427–6440. PMC 84612. PMID 10454588.
- Trivier E, Ganesan TS (2002). „RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.”. J. Biol. Chem. 277 (25): 23037–43. DOI:10.1074/jbc.M202486200. PMID 11956217.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Brandenberger R, Wei H, Zhang S, et al. (2005). „Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.”. Nat. Biotechnol. 22 (6): 707–16. DOI:10.1038/nbt971. PMID 15146197.
- Lu W, Yamamoto V, Ortega B, Baltimore D (2004). „Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.”. Cell 119 (1): 97–108. DOI:10.1016/j.cell.2004.09.019. PMID 15454084.
- Watanabe A, Akita S, Tin NT, et al. (2006). „A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate.”. Cleft Palate Craniofac. J. 43 (3): 310–6. DOI:10.1597/04-145R1.1. PMID 16681403.
- Szafranski K, Schindler S, Taudien S, et al. (2007). „Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.”. Genome Biology 8 (8): R154. DOI:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.