RS-67333
(Preusmjereno sa stranice RS-67,333)
RS-67,333 je psihoaktivni lek i istraživačka hemikalija koja se ispituje kao potencijalni brzo delujući antidepresiv,[1] nootropik,[2] i tretman za Alchajmerovu bolest.[3] On ima parcijalni agonist visokog afiniteta za 5-HT4 receptor, kao i ligand za sigma receptor sa preferencijom za σ1 tip.[4]
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 1-(4-amino-5-hloro-2-metoksifenil)-3-(1-butil-4-piperidinil)-1-propanon | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 160845-95-4 | ||
| ATC kod | nije dodeljen | ||
| Hemijski podaci | |||
| Formula | C19H29N2O2 | ||
| Mol. masa | 352,9 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Reference
uredi- ↑ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). „Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.”. Neuron. 55 (5): 712–25. DOI:10.1016/j.neuron.2007.07.041. PMID 17785179.
- ↑ Lamirault L, Simon H. (2001). „Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.”. Neuropharmacology. 41 (7): 844–53. DOI:10.1016/S0028-3908(01)00123-X. PMID 11684148.
- ↑ Cho S, Hu Y. (2007). „Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.”. Experimental Neurology 203 (1): 274–8. DOI:10.1016/j.expneurol.2006.07.021. PMID 16978609.
- ↑ Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD (August 1995). „Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo”. Br. J. Pharmacol. 115 (8): 1387–92. PMC 1908873. PMID 8564196.
