Replikacioni protein A1
(Preusmjereno sa stranice RF-A)
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Replikacioni protein A, 70 kDa DNK vezujuća podjedinica je protein koji je kod ljudi kodiran RPA1 genom.[1]
| Replikacioni protein A1, 70kDa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz bazira na 1ewi. | |||||||||||
| Dostupne strukture | |||||||||||
| 1EWI, 1FGU, 1JMC, 1L1O, 2B29, 2B3G, 4IJH, 4IJL, 4IPC, 4IPD, 4IPG, 4IPH | |||||||||||
| Identifikatori | |||||||||||
| Simboli | RPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70 | ||||||||||
| Vanjski ID | OMIM: 179835 MGI: 1915525 HomoloGene: 2208 GeneCards: RPA1 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6117 | 68275 | |||||||||
| Ensembl | ENSG00000132383 | ENSMUSG00000000751 | |||||||||
| UniProt | P27694 | Q8VEE4 | |||||||||
| Ref. Sekv. (iRNK) | NM_002945 | NM_001164223 | |||||||||
| Ref. Sekv. (protein) | NP_002936 | NP_001157695 | |||||||||
| Lokacija (UCSC) | Chr 17: 1.73 - 1.8 Mb | Chr 11: 75.3 - 75.35 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Interakcije
urediReplikacioni protein A1 formira interakcije sa RPA2,[2][3] RPA3,[3][4] MCM6,[5] MCM7,[5] MUTYH,[6] BRCA2,[7] ORC6L,[5] ORC2L,[5] TP53BP1,[8] MCM4,[5] P53,[9][10] XPA,[11] MCM2,[5] TIPIN[12] i protein blum sindroma.[13][14][15]
Reference
uredi- ↑ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (April 1993). „Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A”. J Biol Chem 268 (9): 6131–8. PMID 8454588.
- ↑ Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (March 1999). „Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes”. EMBO J. (ENGLAND) 18 (5): 1397–406. DOI:10.1093/emboj/18.5.1397. ISSN 0261-4189. PMC 1171229. PMID 10064605.
- ↑ 3,0 3,1 Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (April 2002). „Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA”. EMBO J. (England) 21 (7): 1855–63. DOI:10.1093/emboj/21.7.1855. ISSN 0261-4189. PMC 125950. PMID 11927569.
- ↑ Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (February 1998). „The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain”. J. Biol. Chem. (UNITED STATES) 273 (7): 3932–6. DOI:10.1074/jbc.273.7.3932. ISSN 0021-9258. PMID 9461578.
- ↑ 5,0 5,1 5,2 5,3 5,4 5,5 Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (March 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
- ↑ Parker, A; Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L (February 2001). „Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair”. J. Biol. Chem. (United States) 276 (8): 5547–55. DOI:10.1074/jbc.M008463200. ISSN 0021-9258. PMID 11092888.
- ↑ Wong, Johnson M S; Ionescu Daniela, Ingles C James (January 2003). „Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2”. Oncogene (England) 22 (1): 28–33. DOI:10.1038/sj.onc.1206071. ISSN 0950-9232. PMID 12527904.
- ↑ Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (August 2005). „53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage”. Oncogene (England) 24 (35): 5423–30. DOI:10.1038/sj.onc.1208710. ISSN 0950-9232. PMID 15856006.
- ↑ Romanova, Larisa Y; Willers Henning, Blagosklonny Mikhail V, Powell Simon N (Dec 2004). „The interaction of p53 with replication protein A mediates suppression of homologous recombination”. Oncogene (England) 23 (56): 9025–33. DOI:10.1038/sj.onc.1207982. ISSN 0950-9232. PMID 15489903.
- ↑ Riva, F; Zuco V, Vink A A, Supino R, Prosperi E (Dec 2001). „UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells”. Carcinogenesis (England) 22 (12): 1971–8. DOI:10.1093/carcin/22.12.1971. ISSN 0143-3334. PMID 11751427.
- ↑ Li, L; Lu X, Peterson C A, Legerski R J (October 1995). „An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair”. Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690.
- ↑ Unsal-Kaçmaz, Keziban; Chastain Paul D, Qu Ping-Ping, Minoo Parviz, Cordeiro-Stone Marila, Sancar Aziz, Kaufmann William K (April 2007). „The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement”. Mol. Cell. Biol. (United States) 27 (8): 3131–42. DOI:10.1128/MCB.02190-06. ISSN 0270-7306. PMC 1899931. PMID 17296725.
- ↑ Brosh, R M; Li J L, Kenny M K, Karow J K, Cooper M P, Kureekattil R P, Hickson I D, Bohr V A (August 2000). „Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity”. J. Biol. Chem. (UNITED STATES) 275 (31): 23500–8. DOI:10.1074/jbc.M001557200. ISSN 0021-9258. PMID 10825162.
- ↑ Opresko, Patricia L; von Kobbe Cayetano, Laine Jean-Philippe, Harrigan Jeanine, Hickson Ian D, Bohr Vilhelm A (October 2002). „Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases”. J. Biol. Chem. (United States) 277 (43): 41110–9. DOI:10.1074/jbc.M205396200. ISSN 0021-9258. PMID 12181313.
- ↑ Moens, Peter B; Kolas Nadine K, Tarsounas Madalena, Marcon Edyta, Cohen Paula E, Spyropoulos Barbara (April 2002). „The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination”. J. Cell. Sci. (England) 115 (Pt 8): 1611–22. ISSN 0021-9533. PMID 11950880.
Literatura
uredi- Iftode C, Daniely Y, Borowiec JA (1999). „Replication protein A (RPA): the eukaryotic SSB.”. Crit. Rev. Biochem. Mol. Biol. 34 (3): 141–80. DOI:10.1080/10409239991209255. PMID 10473346.
- Binz SK, Sheehan AM, Wold MS (2005). „Replication protein A phosphorylation and the cellular response to DNA damage.”. DNA Repair (Amst.) 3 (8-9): 1015–24. DOI:10.1016/j.dnarep.2004.03.028. PMID 15279788.
- Dornreiter I, Erdile LF, Gilbert IU, et al. (1992). „Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.”. EMBO J. 11 (2): 769–76. PMC 556510. PMID 1311258.
- Erdile LF, Heyer WD, Kolodner R, Kelly TJ (1991). „Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication.”. J. Biol. Chem. 266 (18): 12090–8. PMID 2050703.
- Li L, Lu X, Peterson CA, Legerski RJ (1995). „An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.”. Mol. Cell. Biol. 15 (10): 5396–402. PMC 230789. PMID 7565690.
- Keshav KF, Chen C, Dutta A (1995). „Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.”. Mol. Cell. Biol. 15 (6): 3119–28. PMC 230543. PMID 7760808.
- Umbricht CB, Griffin CA, Hawkins AL, et al. (1994). „High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3).”. Genomics 20 (2): 249–57. DOI:10.1006/geno.1994.1161. PMID 8020972.
- Gomes XV, Wold MS (1996). „Functional domains of the 70-kilodalton subunit of human replication protein A.”. Biochemistry 35 (32): 10558–68. DOI:10.1021/bi9607517. PMID 8756712.
- Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L (1997). „Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.”. Nature 385 (6612): 176–81. DOI:10.1038/385176a0. PMID 8990123.
- Amacker M, Hottiger M, Mossi R, Hübscher U (1997). „HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase.”. AIDS 11 (4): 534–6. PMID 9084803.
- Cujec TP, Cho H, Maldonado E, et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.”. Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
- Loor G, Zhang SJ, Zhang P, et al. (1998). „Identification of DNA replication and cell cycle proteins that interact with PCNA.”. Nucleic Acids Res. 25 (24): 5041–6. DOI:10.1093/nar/25.24.5041. PMC 147130. PMID 9396813.
- Bochkareva E, Frappier L, Edwards AM, Bochkarev A (1998). „The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.”. J. Biol. Chem. 273 (7): 3932–6. DOI:10.1074/jbc.273.7.3932. PMID 9461578.
- Golub EI, Gupta RC, Haaf T, et al. (1999). „Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.”. Nucleic Acids Res. 26 (23): 5388–93. DOI:10.1093/nar/26.23.5388. PMC 148005. PMID 9826763.
- Shao RG, Cao CX, Zhang H, et al. (1999). „Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.”. EMBO J. 18 (5): 1397–406. DOI:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605.
- Brosh RM, Orren DK, Nehlin JO, et al. (1999). „Functional and physical interaction between WRN helicase and human replication protein A.”. J. Biol. Chem. 274 (26): 18341–50. DOI:10.1074/jbc.274.26.18341. PMID 10373438.
- Kim ST, Lim DS, Canman CE, Kastan MB (2000). „Substrate specificities and identification of putative substrates of ATM kinase family members.”. J. Biol. Chem. 274 (53): 37538–43. DOI:10.1074/jbc.274.53.37538. PMID 10608806.
- Brosh RM, Li JL, Kenny MK, et al. (2000). „Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.”. J. Biol. Chem. 275 (31): 23500–8. DOI:10.1074/jbc.M001557200. PMID 10825162.