Kompleks prepoznavanja mesta početka, podjedinica 6
(Preusmjereno sa stranice ORC6L)
| edit |
Kompleks prepoznavanja mesta početka, podjedinica 6 je protein koji je kod ljudi kodiran ORC6 (ORC6L) genom.[1][2]
| Kompleks prepoznavanja mesta početka, podjedinica 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dostupne strukture | |||||||||||
| 3M03 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | ORC6; ORC6L | ||||||||||
| Vanjski ID | OMIM: 607213 MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23594 | 56452 | |||||||||
| Ensembl | ENSG00000091651 | ENSMUSG00000031697 | |||||||||
| UniProt | Q9Y5N6 | Q3TQX1 | |||||||||
| Ref. Sekv. (iRNK) | NM_014321 | NM_001163791 | |||||||||
| Ref. Sekv. (protein) | NP_055136 | NP_001157263 | |||||||||
| Lokacija (UCSC) | Chr 16: 46.72 - 46.73 Mb | Chr 8: 85.3 - 85.31 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
| Identifikatori | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Simbol | ORC6 | ||||||||
| Pfam | PF05460 | ||||||||
| InterPro | IPR008721 | ||||||||
| |||||||||
Funkcija
urediProtein kodiran ovim genom je podjedinica ORC kompleksa. Pokazano je da su ORC6 i ORC1 labavo povezani sa sržnim kompleskom koji sarži ORC2, -3, -4 i -5. Studije genskog blokiranja dejstvom male interferirajuće RNK su pokazale da ovaj protein ima esencijalnu ulogu u koordinaciji hromozomske replikacije segregacije.[2]
Interakcije
urediORC6 formira interakcije sa MCM5,[3] ORC2,[3][4] replikacioni protein A1,[3] ORC4,[3] DBF4,[3] ORC3,[3][4] CDC45-srodni protein,[3] MCM4[3] i proteinska kinaza srodna ciklusu 7 ćelijske deobe.[3]
References
uredi- ↑ Dhar SK, Dutta A (Nov 2000). „Identification and characterization of the human ORC6 homolog”. J Biol Chem 275 (45): 34983–8. DOI:10.1074/jbc.M006069200. PMID 10945994.
- ↑ 2,0 2,1 „Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)”.
- ↑ 3,0 3,1 3,2 3,3 3,4 3,5 3,6 3,7 3,8 Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
- ↑ 4,0 4,1 Vashee, S; Simancek P, Challberg M D, Kelly T J (Jul 2001). „Assembly of the human origin recognition complex”. J. Biol. Chem. (United States) 276 (28): 26666–73. DOI:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433.
Literatura
uredi- Li JJ, Herskowitz I (1994). „Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system”. Science 262 (5141): 1870–4. DOI:10.1126/science.8266075. PMID 8266075.
- Jiang W, McDonald D, Hope TJ, Hunter T (1999). „Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication”. EMBO J. 18 (20): 5703–13. DOI:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
- Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). „Assembly of the human origin recognition complex”. J. Biol. Chem. 276 (28): 26666–73. DOI:10.1074/jbc.M102493200. PMID 11323433.
- Chesnokov I, Remus D, Botchan M (2001). „Functional analysis of mutant and wild-type Drosophila origin recognition complex”. Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11997–2002. DOI:10.1073/pnas.211342798. PMC 59756. PMID 11593009.
- Prasanth SG, Prasanth KV, Stillman B (2002). „Orc6 involved in DNA replication, chromosome segregation, and cytokinesis”. Science 297 (5583): 1026–31. DOI:10.1126/science.1072802. PMID 12169736.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. PMID 12614612.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Ramachandran N, Hainsworth E, Bhullar B i dr.. (2004). „Self-assembling protein microarrays”. Science 305 (5680): 86–90. DOI:10.1126/science.1097639. PMID 15232106.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W i dr.. (2004). „From ORFeome to biology: a functional genomics pipeline”. Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Sibani S, Price GB, Zannis-Hadjopoulos M (2005). „Ku80 binds to human replication origins prior to the assembly of the ORC complex”. Biochemistry 44 (21): 7885–96. DOI:10.1021/bi047327n. PMID 15910003.
- Mehrle A, Rosenfelder H, Schupp I i dr.. (2006). „The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415–8. DOI:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Olsen JV, Blagoev B, Gnad F i dr.. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.