Polimeraza
Polimeraza (EC 2.7.7.6/7/19/48/49) je enzim čija centralna funkcije je formiranje polimera nukleinskih kiselina kao što su RNK i DNK.[1] Reakcija polimerizacije nove DNK ili RNK se izvodi koristeći postojeći DNK ili RNK templet u procesima replikacije i transkripcije. U sprezi sa klasterom drugih enzima i proteina, polimeraza koristi nukleotide iz rastvora, i katalizuje sintezu polinukleotidne sekvence sledeći lanac nukleotidnog templeta.[2]
Struktura Taq DNK polimeraze
Vidi jošUredi
- DNK polimeraza
- DNK polimeraza I
- DNK polimeraza II
- DNK polimeraza III holoenzim
- DNK polimeraza IV (DinB) – SOS polimeraza popravke
- RNK polimeraza
ReferenceUredi
- ↑ Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.
- ↑ Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell. New York: Garlard Science. ISBN 0-8153-3218-1.
LiteraturaUredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.