Pleuromutilin

Pleuromutilin
	(4R,5S,6S,8R,9aR,10R)-6-Etenil-5-hidroksi-4,6,9,10-tetrametil-1-oksodekahidro-3a,9-propanociklopenta[8]anulen-8-il hidroksiacetat
Identifikacija
CAS registarski broj	125-65-5
PubChem	31326
ChEMBL	CHEMBL497295
Jmol-3D slike	Slika 1
SMILES
	CC12C(C)CCC3(CCC(=O)C23)C(C)C(O)C(C)(C=C)CC1OC(=O)CO
Svojstva
Molekulska formula	C22H34O5
Molarna masa	378,502 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Pleuromutilin i njegovi derivati su antibakterijski lekovi koji inhiviraju proteinsku sintezu u bakterijama putem vezivanja za peptidil transferaznu komponentu 50S podjedinicu ribozomas.^[4]^[5]

Ova klasa antibiotika obuhvata retapamulin (odobren za topičku primenu kod ljudi), valnemulin i tiamulin (odobren za upotrebu na životinjama) i lekove koji se istražuju azamulin i BC-3781.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Long, Katherine S (April 2006). „Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center”. Antimicrobial Agents and Chemotherapy 50 (4): 1458–1462. DOI:10.1128/AAC.50.4.1458-1462.2006. PMC 1426994. PMID 16569865. Arhivirano iz originala na datum 2011-06-11. Pristupljeno 2014-04-11.
↑ Lolk, L.; Pøhlsgaard, J.; Jepsen, A. S.; Hansen, L. H.; Nielsen, H.; Steffansen, S. I.; Sparving, L.; Nielsen, A. B. i dr.. (2008). „A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome”. Journal of Medicinal Chemistry 51 (16): 4957–4967. DOI:10.1021/jm800261u. PMID 18680270.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] Long, Katherine S (April 2006). „Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center”. Antimicrobial Agents and Chemotherapy 50 (4): 1458–1462. DOI:10.1128/AAC.50.4.1458-1462.2006. PMC 1426994. PMID 16569865. Arhivirano iz originala na datum 2011-06-11. Pristupljeno 2014-04-11.

[5] Lolk, L.; Pøhlsgaard, J.; Jepsen, A. S.; Hansen, L. H.; Nielsen, H.; Steffansen, S. I.; Sparving, L.; Nielsen, A. B. i dr.. (2008). „A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome”. Journal of Medicinal Chemistry 51 (16): 4957–4967. DOI:10.1021/jm800261u. PMID 18680270.

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