EP4 receptor

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Prostaglandinski E receptor 4 (EP₄) je prostaglandinski receptor kodiran PTGER4 genom kod ljudi.

Prostaglandinski E receptor 4
Identifikatori
Simboli	PTGER4; EP4; EP4R
Vanjski ID	OMIM: 601586 MGI: 104311 HomoloGene: 20261 IUPHAR: EP4 GeneCards: PTGER4 Gene
Ontologija gena Molekularna funkcija • aktivnost prostaglandinskog E receptora • proteinskog vezivanje Celularna komponenta • ćelijska membrana • integralno sa membranom Biološki proces • imunski respons • signalni put adenilat ciklazom modulisanog G-protein spregnutog receptora • JNK kaskada
Ortolozi
Vrsta	Čovek	Miš
Entrez	5734	19219
Ensembl	ENSG00000171522	ENSMUSG00000039942
UniProt	P35408	P32240
RefSeq (mRNA)	NM_000958.2	NM_001136079.1
RefSeq (protein)	NP_000949.1	NP_001129551.1
Lokacija (UCSC)	Chr 5: 40.68 - 40.69 Mb	Chr 15: 5.16 - 5.19 Mb
PubMed pretraga	[1]	[2]

Protein kodiran ovim genom je član familije G protein spregnutih receptora. Ovaj protein je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). On može da aktivira signalizaciju T-ćelijskog faktora. Pokazano je posreduje PGE2 indukovano izražavanje EGR1 faktora, reguliše nivo i stabilnost cikloksigenaze-2 iRNK, i dovodi do fosforilacije glikogen sintaze kinaze-3. Studije na nokaut miševima sugeriraju da ovaj receptor učestvuje u neonatalnoj adaptaciji circulatornog sistema, osteoporozi, kao i inicijaciji kožnog imunskog responsa.

Literatura

• Duncan AM, Anderson LL, Funk CD i dr.. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
• Regan JW, Bailey TJ, Pepperl DJ i dr.. (1994). „Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype”. Mol. Pharmacol. 46 (2): 213–20. PMID 8078484. 
• Bastien L, Sawyer N, Grygorczyk R i dr.. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype”. J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
• An S, Yang J, Xia M, Goetzl EJ (1994). „Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2”. Biochem. Biophys. Res. Commun. 197 (1): 263–70. DOI:10.1006/bbrc.1993.2470. PMID 8250933. 
• Foord SM, Marks B, Stolz M i dr.. (1996). „The structure of the prostaglandin EP4 receptor gene and related pseudogenes”. Genomics 35 (1): 182–8. DOI:10.1006/geno.1996.0337. PMID 8661119. 
• Fedyk ER, Phipps RP (1996). „Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells”. Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10978–83. DOI:10.1073/pnas.93.20.10978. PMC 38269. PMID 8855294. 
• Mori K, Tanaka I, Kotani M i dr.. (1996). „Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester”. J. Mol. Med. 74 (6): 333–6. DOI:10.1007/BF00207510. PMID 8862514. 
• Mukhopadhyay P, Geoghegan TE, Patil RV i dr.. (1997). „Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells”. Biochem. Pharmacol. 53 (9): 1249–55. DOI:10.1016/S0006-2952(97)00011-7. PMID 9214685. 
• Cosme R, Lublin D, Takafuji V i dr.. (2000). „Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression”. Hum. Immunol. 61 (7): 684–96. DOI:10.1016/S0198-8859(00)00131-2. PMID 10880739. 
• Desai S, April H, Nwaneshiudu C, Ashby B (2001). „Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration”. Mol. Pharmacol. 58 (6): 1279–86. PMID 11093764. 
• Sales KJ, Katz AA, Davis M i dr.. (2001). „Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors”. J. Clin. Endocrinol. Metab. 86 (5): 2243–9. DOI:10.1210/jc.86.5.2243. PMC 2694306. PMID 11344234. 
• Faour WH, He Y, He QW i dr.. (2001). „Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts”. J. Biol. Chem. 276 (34): 31720–31. DOI:10.1074/jbc.M104036200. PMID 11423555. 
• Desai S, Ashby B (2001). „Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor”. FEBS Lett. 501 (2–3): 156–60. DOI:10.1016/S0014-5793(01)02640-0. PMID 11470276. 
• Slipetz D, Buchanan S, Mackereth C i dr.. (2001). „Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail”. Biochem. Pharmacol. 62 (8): 997–1012. DOI:10.1016/S0006-2952(01)00742-0. PMID 11597569. 
• Fujino H, West KA, Regan JW (2002). „Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2”. J. Biol. Chem. 277 (4): 2614–9. DOI:10.1074/jbc.M109440200. PMID 11706038. 
• Mutoh M, Watanabe K, Kitamura T i dr.. (2002). „Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis”. Cancer Res. 62 (1): 28–32. PMID 11782353. 
• Kvirkvelia N, Vojnovic I, Warner TD i dr.. (2002). „Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells”. Clin. Exp. Immunol. 127 (2): 263–9. DOI:10.1046/j.1365-2249.2002.01718.x. PMC 1906325. PMID 11876748. 
• Asano T, Shoda J, Ueda T i dr.. (2002). „Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression”. Clin. Cancer Res. 8 (4): 1157–67. PMID 11948128. 
• Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR”. Mol. Vis. 8: 51–8. PMID 11951086. 
• Scandella E, Men Y, Gillessen S i dr.. (2002). „Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells”. Blood 100 (4): 1354–61. DOI:10.1182/blood-2001-11-0017. PMID 12149218. 

Povezano

• Eikozanoidni receptor

Spoljašnje veze

• „Prostanoid Receptors: EP₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.