Prostaglandin-E2 9-reduktaza
Prostaglandin-E2 9-reduktaza (EC 1.1.1.189, PGE2-9-OR, reduktaza, 15-hidroksi-9-oksoprostaglandin, 9-keto-prostaglandin E2 reduktaza, 9-ketoprostaglandin reduktaza, PGE-9-ketoreduktaza, PGE2 9-oksoreduktaza, PGE2-9-ketoreduktaza, prostaglandin 9-ketoreduktaza, prostaglandin E 9-ketoreduktaza, prostaglandin E2-9-oksoreduktaza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat:NADP+ 9-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Prostaglandin-E2 9-reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.189 | ||||||||
| CAS broj | 42613-35-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat + NADP+ (5Z,13E)-(15S)-11alfa,15-dihidroksi-9-oksoprosta-5,13-dienoat + NADPH + H+
Ovaj enzim redukuje prostaglandin E2 do prostaglandina F2alfa. Brojni drugi 9-okso- i 15-okso-prostaglandinski derivati takođe mogu da budu redukovani do korespondirajućih hidroksi jedinjenja. Može da bude identičan sa EC 1.1.1.197, 15-hidroksiprostaglandin dehidrogenazom (NADP+).
Reference
uredi- ↑ Lee, S.-C. and Levine, L. (1975). „Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase”. J. Biol. Chem. 250: 4549-4555. PMID 166995.
- ↑ Schlegel, W., Krüger, S. and Korte, K. (1984). „Purification of prostaglandin E2 9-oxoreductase from human decidua vera”. FEBS Lett. 171: 141-144. PMID 6586494.
- ↑ Tai, H.-H. and Yuan, B. (1982). „Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney”. Methods Enzymol. 86: 113-117. PMID 7132747.
- ↑ Watkins, J.D. and Jarabak, J. (1985). „The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney”. Prostaglandins 30: 335-349. PMID 3901124.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.