Glicin dehidrogenaza (dekarboksilacija)
(Preusmjereno sa stranice P-protein)
Glicin dehidrogenaza (dekarboksilacija) (EC 1.4.4.2, P-protein, glicinska dekarboksilaza, glicin:lipoilprotein oksidoreduktaza (dekarboksilacija i aminometilacija akceptora), protein P1) je enzim sa sistematskim imenom glicin:H-protein-lipoilizin oksidoreduktaza (dekarboksilacija, akceptor-amino-metilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicin dehidrogenaza (dekarboksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.4.2 | ||||||||
| CAS broj | 37259-67-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- glicin + H-protein-lipoillizin H-protein-S-aminometildihidrolipoilizin + CO2
Ovaj enzim je piridoksal-fosfatni protein. On zajedno sa EC 2.1.2.10, aminometiltransferazom i EC 1.8.1.4, dihidrolipoil dehidrogenanzom sačinjava sistem glicinskog odvajanja, koji je ranije bio poznat kao glicinska sintaza.
Reference uredi
- ↑ Hiraga, K. and Kikuchi, G. (1980). „The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein”. J. Biol. Chem. 255: 11671-11676. PMID 7440563.
- ↑ Perham, R.N. (2000). „Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions”. Annu. Rev. Biochem. 69: 961-1004. PMID 10966480.
- ↑ Nesbitt, N.M., Baleanu-Gogonea, C., Cicchillo, R.M., Goodson, K., Iwig, D.F., Broadwater, J.A., Haas, J.A., Fox, B.G. and Booker, S.J. (2005). „Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase”. Protein Expr. Purif. 39: 269-282. PMID 15642479.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.