Nitrit reduktaza (NAD(P)H)

Nitrit reduktaza (NAD(P)H)
Identifikatori
EC broj	1.7.1.4
CAS broj	9029-29-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Nitrit reduktaza (NAD(P)H) (EC 1.7.1.4, nitritna reduktaza (redukovani nikotinamid adenin dinukleotid (fosfat)), NADH-nitritna oksidoreduktaza, NADPH-nitritna reduktaza, asimilatorna nitritna reduktaza, nitritna reduktaza (NAD(P)H2), NAD(P)H₂:nitrit oksidoreduktaza) je enzim sa sistematskim imenom amonijum-hidroksid:NAD(P)⁺ oksidoreduktaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

amonijum hidroksid + 3 NAD(P)⁺ +H₂O

\rightleftharpoons

nitrit + 3 NAD(P)H + 3 H⁺

Ovaj enzim je flavoprotein koji sadrži gvožđe-sumpor hem.

Reference

↑ Cammack, R., Jackson, R.H., Cornish-Bowden, A. and Cole, J.A. (1982). „Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12”. Biochem. J. 207: 333-339. PMID 6297458.
↑ Lazzarini, R.A. and Atkinson, D.E. (1961). „A triphosphopyridine nucleotide-specific nitrite reductase from Escherichia coli”. J. Biol. Chem. 236: 3330-3335. PMID 14463130.
↑ Nicholas, D.J.D., Medina, A. and Jones, O.T.G. (1960). „A nitrite reductase from Neurospora crassa”. Biochim. Biophys. Acta 37: 468-468.
↑ Taniguchi, H., Mitsui, H., Nakamura, K. and Egami, F. (1955). „Hydoxylamine reductase”. Ann. Acad. Sci. Fenn. Ser. A II 60: 200-200.
↑ Colandene, J.D. and Garrett, R.H. (1996). „Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa”. J. Biol. Chem. 271: 24096-24104. PMID 8798648.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Nitrite+reductase+(NAD(P)H)

[1] Cammack, R., Jackson, R.H., Cornish-Bowden, A. and Cole, J.A. (1982). „Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12”. Biochem. J. 207: 333-339. PMID 6297458.

[2] Lazzarini, R.A. and Atkinson, D.E. (1961). „A triphosphopyridine nucleotide-specific nitrite reductase from Escherichia coli”. J. Biol. Chem. 236: 3330-3335. PMID 14463130.

[3] Nicholas, D.J.D., Medina, A. and Jones, O.T.G. (1960). „A nitrite reductase from Neurospora crassa”. Biochim. Biophys. Acta 37: 468-468.

[4] Taniguchi, H., Mitsui, H., Nakamura, K. and Egami, F. (1955). „Hydoxylamine reductase”. Ann. Acad. Sci. Fenn. Ser. A II 60: 200-200.

[5] Colandene, J.D. and Garrett, R.H. (1996). „Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa”. J. Biol. Chem. 271: 24096-24104. PMID 8798648.

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