Naltriben je potentan i selektivan antagonist delta opioidnog receptora, koji se koristi u naučnim istraživanjima. On ima slične efekte sa δ antagonistom naltrindolom koji je u široj upotrebi. Naltriben ima različit afinitet vezivanja za δ1 i δ2 tipove, iz kog razloga je koristan u određivanju osobina receptorskih izofromi.[4] On takođe deluje kao κ-opioidni agonist u visokim dozama.[5]
Naltriben
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Klinički podaci
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Identifikatori
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CAS broj
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111555-58-9
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ATC kod
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nije dodeljen
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PubChem[1][2]
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5486827
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ChemSpider[3]
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4589081
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Hemijski podaci
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Formula
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C26H25NO4
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Mol. masa
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415.480 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 Y Key: ZHVWWEYETMPAMX-IFKAHUTRSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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Literatura
uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
- ↑ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443
Spoljašnje veze
uredi