N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-(N6-triglicin)-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin:glicin gliciltransferaza
N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-(N6-triglicin)-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin:glicin gliciltransferaza (EC 2.3.2.18, femB (gen)) je enzim sa sistematskim imenom N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-(N6-triglicin)-D-alanil-D-alanin-ditrans,oktacis-difosfoundekaprenil-N-acetilglukozamin:glicin gliciltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-(N6-triglicin)-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin:glicin gliciltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.3.2.18 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-(N6-triglicil)-D-alanil-D-alanin-difosfo-ditrans,oktacis-undekaprenil-N-acetilglukozamin + 2 glicil-tRNK N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-(N6-pentaglicil)-D-alanil-D-alanin-difosfo-ditrans,oktacis-undekaprenil-N-acetilglukozamin + 2 tRNK
Ovaj enzim iz Staphylococcus aureus katalizuje uzastopne prenose dva glicina sa naelektrisanih tRNK molekula na N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-(N6-triglicil)-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin, vezujuči ih na glicine koji su prethodno dodati na N6 L-lizina u poziciji 3 pentapeptida posredstvom enzima EC 2.3.2.16 (lipid II:glicin gliciltransferaza) i EC 2.3.2.17 (N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-(N6-glicil)-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin:glicin gliciltransferaza).
Reference uredi
- ↑ Ehlert, K., Schroder, W. and Labischinski, H. (1997). „Specificities of FemA and FemB for different glycine residues: FemB cannot substitute for FemA in staphylococcal peptidoglycan pentaglycine side chain formation”. J. Bacteriol. 179: 7573-7576. PMID 9393725.
- ↑ Rohrer, S. and Berger-Bachi, B. (2003). „Application of a bacterial two-hybrid system for the analysis of protein-protein interactions between FemABX family proteins”. Microbiology 149: 2733-2738. PMID 14523106.
- ↑ Schneider, T., Senn, M.M., Berger-Bachi, B., Tossi, A., Sahl, H.G. and Wiedemann, I. (2004). „In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus”. Mol. Microbiol. 53: 675-685. PMID 15228543.
Literatura uredi
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
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