Glicilpeptid N-tetradekanoiltransferaza
(Preusmjereno sa stranice Myristoyl-CoA-protein N-myristoyltransferase)
Glicilpeptid N-tetradekanoiltransferaza (EC 2.3.1.97, peptid N-miristoiltransferaza, miristoil-KoA-protein N-miristoiltransferaza, miristoil-koenzim A:protein N-miristoil transferaza, miristoilacioni enzim, protein N-miristoiltransferaza) je enzim sa sistematskim imenom tetradekanoil-KoA:glicilpeptid N-tetradekanoiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicilpeptid N-tetradekanoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.97 | ||||||||
| CAS broj | 110071-61-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tetradekanoil-KoA + glicilpeptid KoA + N-tetradekanoilglicilpeptid
Enzim iz kvasca je veoma specifičan za tetradekanoil-KoA, za N-terminalni glicin u oligopeptidima koji sadrže serin u 5-pozicija. Enzim iz srca sisara prenosi grupe na specifične 51 kDa akceptorske proteine.
Reference
uredi- ↑ Guertin, D., Gris-Miron, L. and Riendeau, D. (1986). „Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue”. Biochem. Cell Biol. 64: 1249-1255. PMID 3566958.
- ↑ Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I. (1988). „11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase”. J. Biol. Chem. 263: 2127-2133. PMID 3123489.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.