TRNK (adenin57-N1/adenin58-N1)-metiltransferaza
(Preusmjereno sa stranice MtTrmI)
TRNK (adenin57-N1/adenin58-N1)-metiltransferaza (EC 2.1.1.219, TrmI, PabTrmI, AqTrmI, MtTrmI) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin57/adenin58-N1)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK (adenin57-N1/adenin58-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.219 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 S-adenozil-L-metionin + adenin57/adenin58 u tRNK 2 S-adenozil-L-homocistein + N1-metiladenin57/N1-metiladenin58 u tRNK
Ovaj enzim katalizuje formiranje N1-metiladenina u dve susedne pozicije (57 i 58) u T-petlji pojedinih tRNK molekula (e.g. tRNKAsp). Metiladenozin u poziciji 57 je obligatorni intermedijer za sintezu metilinozina, koji je obično prisutan u poziciji 57 arhejnih tRNK molekula.
Reference uredi
- ↑ Roovers, M., Wouters, J., Bujnicki, J.M., Tricot, C., Stalon, V., Grosjean, H. and Droogmans, L. (2004). „A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase”. Nucleic Acids Res. 32: 465-476. PMID 14739239.
- ↑ Guelorget, A., Roovers, M., Guerineau, V., Barbey, C., Li, X. and Golinelli-Pimpaneau, B. (2010). „Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase”. Nucleic Acids Res. 38: 6206-6218. PMID 20483913.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.