Mikrobna kolagenaza
Mikrobna kolagenaza (EC 3.4.24.3, Clostridium histolyticum kolagenaza, klostridiopeptidaza A, kolagenaza A, kolagenaza I, Achromobacter iophagus kolagenaza, kolagenaza, aspergilopeptidaza C, nukleolizin, azokolaza, metalokolagenaza, soikolagestin, Clostridium histolyticum proteinaza A, klostridiopeptidaza II, MMP-8, klostridiopeptidaza I, kolagenska peptidaza, kolagenska proteaza, kolagenaza MMP-1, metaloproteinaza-1, kolaza, matriks metaloproteinaza-1, MMP-1, matriks metaloproteinaza-8, matriks metaloproteinaza-18) je enzim.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
Mikrobna kolagenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.3 | ||||||||
CAS broj | 2593923 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Varenje prirodnog kolagena u regionu trostrukog heliksa na -Gly vezama. Na sintetičkim peptidima preferentno deluje na Gly u P3 i P1', Pro i Ala u P2 i P2', i hidroksiprolin, Ala ili Arg u P3'
Ovaj enzim je jedan od šest metaloendopeptidaza koji deluju na prirodni kolagen i koji su prisutni u medijumu bakterije Clostridium histolyticum.
Reference uredi
- ↑ Hanada, K., Mizutani, T., Yamagishi, M., Tsuji, H., Misaki, T. Sawada, J. (1973). „The isolation of collagenase and its enzymological and physico-chemical properties”. Agric. Biol. Chem. 37: 1771-1781.
- ↑ Merkel, J.R. and Dreisbach, J.H. (1978). „Purification and characterization of a marine bacterial collagenase”. Biochemistry 17: 2857-2863. PMID 210785.
- ↑ Heindl, M.-C., Fermandjian, S. and Keil, B. (1980). „Circular dichroism comparative studies of two bacterial collagenases and thermolysin”. Biochim. Biophys. Acta 624: 51-59. PMID 6250633.
- ↑ Labadie, J. and Montel, M..-C. (1982). „Purification et étude de quelques propriétés d’une collagénase produite par Empedobacter collagenolyticum”. Biochimie 64: 49-54. PMID 6530724.
- ↑ Bond, M.D and Van Wart, H.D. (1984). „Characterization of the individual collagenases from Clostridium histolyticum”. Biochemistry 23: 3085-3091. PMID 6087888.
- ↑ Bond, M.D. and Van Wart, H.D. (1984). „Relationship between the individual collagenases of Clostridium histolyticum: evidience for evolution by gene duplication”. Biochemistry 23: 3092-3099. PMID 6087889.
- ↑ Van Wart, H.D. and Steinbrink, D.R. (1985). „Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum”. Biochemistry 24: 6520-6526. PMID 3002445.
- ↑ Tong, N.T., Tsugita, A. and Keil-Dlouha, V. (1986). „Purification and characterization of two high-molecular-mass forms of Achromobacter collagenase”. Biochim. Biophys. Acta 874: 296-304.
- ↑ Endo, A., Murakawa, S., Shimizu, H. and Shiraishi, Y. (1987). „Purification and properties of collagenase from a Streptomyces species”. J. Biochem. (Tokyo) 102: 163-170. PMID 2822678.
- ↑ Makinen, K.K. and Makinen, P.-L. (1987). „Purification and properties of an extracellular collagenolytic protease produced by the human oral bacterium Bacillus cereus (strain Soc 67)”. J. Biol. Chem. 262: 12488-12495. PMID 3040751.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.