Membranska dipeptidaza
Membranska dipeptidaza (EC 3.4.13.19, renalna dipeptidaza, dehidropeptidaza I (DPH I), dipeptidaza, aminodipeptidaza, dipeptidna hidrolaza, dipeptidilna hidrolaza, nespecifična dipeptidaza, glikozil-fosfatidilinozitol-učvršćena renalna dipeptidaza, MDP) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Membranska dipeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.13.19 | ||||||||
| CAS broj | 9031-99-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza dipeptida
Ovaj membranski, cinkov enzim ima široku specifičnost. Izobilno je prisutan u bubrežnom korteksu.
Reference uredi
- ↑ Campbell, B., Lin, H., Davis, R. and Ballew, E. (1966). „The purification and properties of a particulate renal dipeptidase”. Biochim. Biophys. Acta 118: 371-386. PMID 5961612.
- ↑ Campbell, B.J. (1970). „Renal dipeptidase”. Methods Enzymol. 19: 722-729.
- ↑ Kropp, H., Sundelof, J.G., Hajdu, R. and Kahan, F.M. (1982). „Metabolism of thienamycin and related carbapenem antibiotics by renal dipeptidase, dehydropeptidase-I”. Antimicrob. Agents Chemother. 22: 62-70. PMID 7125632.
- ↑ Hooper, N.M., Keen, J.N. and Turner, A.J. (1990). „Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme”. Biochem. J. 265: 429-433. PMID 2137335.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.