VUF-6002
(Preusmjereno sa stranice MOIWSUQWIOVGRH-UHFFFAOYSA-N)
VUF-6002 (JNJ 10191584) je lek koji deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[3] On pokazuje antiinflamatorne i analgetske efekte u ispitivanjima akutne inflamacije na životinjama.[4]
(IUPAC) ime | |||
---|---|---|---|
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-benzimidazol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 869497-75-6 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 10446295 | ||
Hemijski podaci | |||
Formula | C13H15ClN4O | ||
Mol. masa | 278,737 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Zhang, M; Thurmond, RL; Dunford, PJ (2007). „The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders”. Pharmacology & therapeutics 113 (3): 594–606. DOI:10.1016/j.pharmthera.2006.11.008. PMID 17275092.
- ↑ Coruzzi, G; Adami, M; Guaita, E; De Esch, IJ; Leurs, R (2007). „Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation”. European Journal of Pharmacology 563 (1–3): 240–4. DOI:10.1016/j.ejphar.2007.02.026. PMID 17382315.