23S rRNK (adenin1618-N6)-metiltransferaza
(Preusmjereno sa stranice M6A1618 methyltransferase)
23S rRNK (adenin1618-N6)-metiltransferaza (EC 2.1.1.181, metiltransferaza F velike podjedinice rRNK, YbiN protein, rlmF (gen), m6A1618 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenin1618-N6)-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 23S rRNK (adenin1618-N6)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.181 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + adenin1618 u 23S rRNK S-adenozil-L-homocistein + N6-metiladenin1618 u 23S rRNK
Rekombinantni YbiN protein ima sposobnost metilacije parcijalno deprotonisane 50 S ribozomalne podjedinice. On ne deluje na kompletno formirane 50 S podjednice, niti na kompletno deprotonisanu 23 S rRNK.
Reference
uredi- ↑ Sergiev, P.V., Serebryakova, M.V., Bogdanov, A.A. and Dontsova, O.A. (2008). „The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel”. J. Mol. Biol. 375: 291-300. PMID 18021804.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.