Lipoproteinska lipaza
Lipoproteinska lipaza (EC 3.1.1.34, digliceridna lipaza, diacilglicerolna lipaza, postheparinska esteraza, digliceridna lipaza, postheparinska lipaza, diacilglicerolna hidrolaza) je enzim sa sistematskim imenom triacilglicero-protein acilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Lipoproteinska lipaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.34 | ||||||||
| CAS broj | 2594722 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- triacilglicerol + H2O diacilglicerol + karboksilat
Ovaj enzim hidrolizuje triacilglicerole u hilomikronima i lipoproteinima niske gustine. On takođe hidrolizuje diacilglicerol.
Reference
uredi- ↑ Egelrud, T. and Olivecrona, T. (1973). „Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors”. Biochim. Biophys. Acta 306: 115-127. PMID 4703566.
- ↑ Fielding, C.J. (1970). „Human lipoprotein lipase. I. Purification and substrate specificity”. Biochim. Biophys. Acta 206: 109-117. PMID 5441398.
- ↑ Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S. (1970). „Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase”. Biochim. Biophys. Acta 210: 39-45. PMID 5466051.
- ↑ Morley, N. and Kuksis, A. (1972). „Positional specificity of lipoprotein lipase”. J. Biol. Chem. 247: 6389-6393. PMID 5076762.
- ↑ Nilsson-Ehle, P., Belfrage, P. and Borgström, B. (1971). „Purified human lipoprotein lipase: positional specificity”. Biochim. Biophys. Acta 248: 114-120. PMID 5168777.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.