Kvercetin 2,3-dioksigenaza
(Preusmjereno sa stranice Kvercetinaza)
Kvercetin 2,3-dioksigenaza (EC 1.13.11.24, kvercetinaza, flavonol 2,4-oksigenaza) je enzim sa sistematskim imenom kvercetin:kiseonik 2,3-oksidoreduktaza (deciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kvercetin 2,3-dioksigenaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 1.13.11.24 | ||||||||
| CAS broj | 9075-67-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- kvercetin + O2 2-(3,4-dihidroksibenzoiloksi)-4,6-dihidroksibenzoat + CO + H+
Enzim iz Aspergillus sp. je bakarni protein, dok enzim iz Bacillus subtilis sadrži gvožđe.
Reference
uredi- ↑ Oka, T. and Simpson, F.J. (1971). „Quercetinase, a dioxygenase containing copper”. Biochem. Biophys. Res. Commun. 43: 1-5. PMID 5579942.
- ↑ Steiner, R.A., Kalk, K.H. and Dijkstra, B.W. (2002). „Anaerobic enzyme·substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase”. Proc. Natl. Acad. Sci. USA 99: 16625-16630. PMID 12486225.
- ↑ Bowater, L., Fairhurst, S.A., Just, V.J. and Bornemann, S. (2004). „Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase”. FEBS Lett. 557: 45-48. PMID 14741339.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.