Konesin

Konesin
Drugi nazivi	N,N-Dimetil-kon-5-enin-3-amin
Identifikacija
CAS registarski broj	546-06-5
PubChem	2860
MeSH	Conessine
ChEMBL	CHEMBL191703
Jmol-3D slike	Slika 1
SMILES
	C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C
InChI
	InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1 ; Kod: GPLGAQQQNWMVMM-MYAJQUOBSA-N
Svojstva
Molekulska formula	C24H40N2
Molarna masa	356,5878
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Konesin je steroidni alkaloid prisutan u brojnim biljnim vrstama iz Apocynaceae familije, uključujući Holarrhena floribunda,^[4] Holarrhena antidysenterica^[5] i Funtumia elastica,^[6] neke od kojih se koriste u tradicionalnom travarstvu kao tretman za amebnu dizenteriju.^[7] On deljuje kao histaminski antagonist, koji je selektivan za H₃ receptor.^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993
↑ Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193
↑ Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333
↑ Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597
↑ Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

Spoljašnje veze uredi

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993

[5] Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193

[6] Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333

[7] Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597

[8] Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

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