Kodeinon reduktaza (NADPH)
Kodeinon reduktaza (NADPH) (EC 1.1.1.247, kodeinonska reduktaza (NADPH)) je enzim sa sistematskim imenom kodein:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kodeinon reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.247 | ||||||||
| CAS broj | 153302-41-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- kodein + NADP+ kodeinon + NADPH + H+
Kodeinonska reduktaza katalizuje reverzibilnu redukciju kodeinona do kodeina, koji je direktni prekurzor morfina u opijumskim biljkama maka, Papaver somniferum]].
Reference uredi
- ↑ Lenz, R. and Zenk, M.H. (1995). „Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum”. Tetrahedron Lett. 36: 2449-2452.
- ↑ Lenz, R. and Zenk, M.H. (1995). „Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures”. Eur. J. Biochem. 233: 132-139. PMID 7588736.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.