Ro10-5824
(Preusmjereno sa stranice KABDATZAOUSYES-UHFFFAOYSA-N)
Ro10-5824 je lek koji deluje kao dopaminski agonist. On je selektivni parcijalni agonist D4 podtipa. Ro10-5824 deluje kao kognitivni pojačivač u životinjskim studijama.[3][4]
(IUPAC) ime | |||
---|---|---|---|
2-metil-5-[(4-fenil-3,6-dihidro-2H-piridin-1-il)metil]pirimidin-4-amin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 189744-46-5 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 16759175 | ||
Hemijski podaci | |||
Formula | C17H20N4 | ||
Mol. masa | 280,367 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). „RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice”. Neuropharmacology 44 (4): 473–81. DOI:10.1016/S0028-3908(02)00412-4. PMID 12646284.
- ↑ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). „Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells”. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307. DOI:10.1017/S1461145707008061. PMID 17897483.