Jodofenpropit je histaminski antagonist koji se selektivno vezuje za histaminski H3 receptor. Njegov 125I radioobeležen oblik se koristi za mapiranje distribucije H3 receptora u telu.[4][5]
Jodofenpropit
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IUPAC ime
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3-(1H-imidazol-5-il)propil N'-[2-(4-jodofenil)etil]imidotiokarbamat |
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Drugi nazivi
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1-[3-(3H-imidazol-4-il)propiltio]-N'-[2-(4-jodofenil)etil]formamidin
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Identifikacija
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CAS registarski broj
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143407-29-8 Y
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PubChem[1][2]
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3035746
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MeSH
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Iodophenpropit
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ChEMBL[3]
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CHEMBL498770 Y
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Jmol-3D slike
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Slika 1
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C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I |
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InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) Y Kod: UBHYDQAARZKHEZ-UHFFFAOYSA-N Y |
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Svojstva
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Molekulska formula
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C15H19IN4S
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Molarna masa
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414,30763
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Y (šta je ovo?)
(verifikuj)
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
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Infobox references
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). „Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain”. British Journal of Pharmacology 113 (2): 355–62. PMC 1510107. PMID 7834183.
- ↑ Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). „Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit”. Naunyn-Schmiedeberg's archives of pharmacology 362 (1): 60–7. DOI:10.1007/s002100000227. PMID 10935534.
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