Interferon alfa 2b
Interferon alfa 2b (Intron-A) antivirusni lek je sa širokim opsegom indikacija, uklučujući viralne infekcije i kancere. Ovaj lek je razvilo preduzeće Biogen. Interferon alfa 2b je tip I interferon, koji se sastoji od 165 aminokiselina sa argininom u poziciji 23. Ovaj protein se proizvodi primenom rekombinantne DNK tehnologije. On je sličan interferonu koji izlučuju leukociti.[3][4][5]
| Klinički podaci | |
|---|---|
| MedlinePlus | a690006 |
| Identifikatori | |
| ATC kod | L03AB05 |
| DrugBank | DB00105 |
| ChemSpider[1] | NA |
| ChEMBL[2] | CHEMBL1201558 
|
| Hemijski podaci | |
| Formula | ? |
| Farmakoinformacioni podaci | |
| Trudnoća | C(US) |
| Pravni status | POM (UK) ℞-only (SAD) |
| Način primene | Subkutano, intramuskularno |
Reference
uredi- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR: Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. Structure. 1996 Dec 15;4(12):1453-63. PMID 8994971
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
