Indol-3-piruvat monooksigenaza
Indol-3-piruvat monooksigenaza (EC 1.14.13.168, YUC2 (gen), spi1 (gen)) je enzim sa sistematskim imenom indol-3-piruvat,NADPH:kiseonik oksidoreduktaza (1-hidroksilacija, dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Indol-3-piruvat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.168 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (indol-3-il)piruvat + NADPH + H+ + O2 (indol-3-il)acetat + NADP+ + H2O + CO2
Ova biljni enzim, zajedno sa EC 2.6.1.99 L-triptofan---piruvat aminotransferazom, je odgovoran za biosintezu biljnog hormona indol-3-acetata iz L-triptofana.
Reference uredi
- ↑ Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y. and Kasahara, H. (2011). „The main auxin biosynthesis pathway in Arabidopsis”. Proc. Natl. Acad. Sci. USA 108: 18512-18517. PMID 22025724.
- ↑ Zhao, Y. (2012). „Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants”. Mol. Plant 5: 334-338. PMID 22155950.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.