Interleukin 14

Interleukin 14
Identifikatori
Simbol	TXNLA
Alt. simboli	HMW-BCGF, IL14
Entrez	3599
Hugo	5976
OMIM	608676
RefSek	NP_787048
UniProt	L15344
Drugi podaci
Lokus	Hrom. 1 p34.3

Interleukin 14 (IL-14) je citokin koji se takođe zove faktor rasta visoke molekulske težine B-ćelija (HMW-BCGF). On kontroliše rast i proliferaciju normalinih i kancerogenih B ćelija.^[1] Ovom molekulu je bio nedavno dato ime taksilin (taxilin).^[2] IL-14 izaziva proliferaciju B-ćelija, inhibira izlučivanje antitela, i proširuje izabrane B-ćelijske podgrupe. Ovaj interleukin proizvode uglavnom T ćelije i neke maligne B ćelije.^[3]^[4]^[5]

Dva različita traskript nastaju iz suprotnih lanaca IL14 gena. Oni se nazivaju IL-14α i IL-14β.^[6] IL14 lokus je blizo gena za LCK na hromozomu 1 kod ljudi.

Reference

↑ Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.
↑ Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28
↑ Snežana Živančević-Simonović Aleksandar Đukić. Opšta patološka fiziologija. Kragujevac: Univerzitet u Kragujevcu medicinski fakultet. ISBN 86-82477-65-3.
↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
↑ Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.

Literatura

Snežana Živančević-Simonović Aleksandar Đukić. Opšta patološka fiziologija. Kragujevac: Univerzitet u Kragujevcu medicinski fakultet. ISBN 86-82477-65-3.

Spoljašnje veze

MeSH Interleukin-14

Wikimedia Commons ima multimedijalne datoteke vezane za: Citokine

[1] Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.

[2] Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28

[Живанчевић-Симоновић-3] Snežana Živančević-Simonović Aleksandar Đukić. Opšta patološka fiziologija. Kragujevac: Univerzitet u Kragujevcu medicinski fakultet. ISBN 86-82477-65-3.

[KubyImmunology6th-4] Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.

[5] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[6] Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.

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