HycI peptidaza
HycI peptidaza (EC 3.4.23.51, HycI, HycE procesujući protein) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| HycI peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.51 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Ovaj enzim specifično uklanja 32 aminokiseline dug peptid sa C-terminusa prekurzora velike podjedinice hidrogenaze 3 u Escherichia coli presecanjem C-terminalnog mesta na Arg537.
Za ovu reakciju je neophodno da je nikal vezan za prekurzor velike podjedinice hidrogenaze 3.
Reference uredi
- ↑ Theodoratou, E., Paschos, A., Magalon, A., Fritsche, E., Huber, R. and Bock, A. (2000). „Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation”. Eur. J. Biochem. 267: 1995-1999. PMID 10727938.
- ↑ Yang, F., Hu, W., Xu, H., Li, C., Xia, B. and Jin, C. (2007). „Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation”. J. Biol. Chem. 282: 3856-3863. PMID 17150961.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.