Holoilglicinska hidrolaza
Holoilglicinska hidrolaza (EC 3.5.1.24, glikoholaza, hidrolaza žučne soli, holoiltaurinska hidrolaza, 3alfa,7alfa,12alfa-trihidroksi-5beta-holan-24-oilglicin amidohidrolaza) je enzim sa sistematskim imenom glikoholat amidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Holoilglicinska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.24 | ||||||||
| CAS broj | 37289-07-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- glikoholat + H2O holat + glicin
Ovaj enzim takođe deluje na 3alfa,12alfa-dihidroksi-derivate, i na holoil-taurin.
Reference uredi
- ↑ Nair, P.P., Gordon, M. and Reback, J. (1967). „The enzymatic cleavage of the carbon-nitrogen bond in 3α,7α,12α-trihydroxy-5-β-cholan-24-oylglycine”. J. Biol. Chem. 242: 7-11. PMID 6016335.
- ↑ Stellwag, E.J. and Hylemon, P.B. (1976). „Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis”. Biochim. Biophys. Acta 452: 165-176. PMID 10993.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.