Hitin sintaza
Hitin sintaza (EC 2.4.1.16, hitin-UDP N-acetilglukozaminiltransferaza, hitin-uridin difosfat acetilglukozaminiltransferaza, hitin sintetaza, trans-N-acetilglukozaminozilaza, UDP-N-acetil-D-glukozamin:hitin 4-beta-N-acetilglukozaminil-transferaza) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin:hitin 4-beta-N-acetilglukosaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hitin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.16 | ||||||||
| CAS broj | 9030-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-alfa-D-glukozamin + [4)-N-acetil-beta-D-glukozaminil-(1->]n UDP + [4)-N-acetil-beta-D-glukozaminil-(1->]n+1
Ovaj enzim konvertuje UDP-N-acetil-alfa-D-glukozamin u hitin i UDP.
Reference
uredi- ↑ Glaser, L. and Brown, D.H. (1957). „The synthesis of chitin in cell-free extracts of Neurospora crassa”. J. Biol. Chem. 228: 729-742. PMID 13475355.
- ↑ Sburlati, A. and Cabib, E. (1986). „Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae”. J. Biol. Chem. 261: 15147-15152. PMID 2945823.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.