Glicin dehidrogenaza (formira cijanid)
(Preusmjereno sa stranice HCN sintaza)
Glicin dehidrogenaza (formira cijanid) (EC 1.4.99.5, cijanovodonična sintaza, HCN sintaza) je enzim sa sistematskim imenom glicin:akceptor oksidoreduktaza (formira cijanovodonik).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicin dehidrogenaza (formira cijanid) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.99.5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- glicin + 2 A hidrogen cijanid + CO2 + 2 AH2
Ova enzim iz Pseudomonas sp. sadrži FAD. On je vezan za membranu.
Reference uredi
- ↑ Wissing, F. (1975). „Cyanide production from glycine by a homogenate from a Pseudomonas species”. J. Bacteriol. 121: 695-699. PMID 234422.
- ↑ Castric, P.A. (1977). „Glycine metabolism by Pseudomonas aeruginosa: Hydrogen cyanide biosynthesis”. J. Bacteriol. 130: 826-831. PMID 233722.
- ↑ Laville, J., Blumer, C., Von Schroetter, C., Gaia, V., Defago, G., Keel, C. and Haas, D. (1998). „Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0”. J. Bacteriol. 180: 3187-3196. PMID 9620970.
- ↑ Blumer, C. and Haas, D. (2000). „Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis”. Arch. Microbiol. 173: 170-177. PMID 10763748.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.