2-Hidroksihromen-2-karboksilatna izomeraza
(Preusmjereno sa stranice HCCA izomeraza)
2-Hidroksihromen-2-karboksilatna izomeraza (EC 5.99.1.4, HCCA izomeraza, 2HC2CA izomeraza, 2-hidroksihromen-2-karboksilno kiselinska izomeraza) je enzim sa sistematskim imenom 2-hidroksi-2H-hromen-2-karboksilat—(3E)-4-(2-hidroksifenil)-2-oksobut-3-enoat izomeraza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Hidroksihromen-2-karboksilatna izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.99.1.4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-hidroksi-2H-hromen-2-karboksilat (3E)-4-(2-hidroksifenil)-2-oksobut-3-enoat
Ovaj enzim učestvuje u degradaciji naftalena.
Reference uredi
- ↑ Ohmoto, T., Kinoshita, T., Moriyoshi, K., Sakai, K., Hamada, N. and Ohe, T. (1998). „Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2”. J. Biochem. 124: 591-597. PMID 9722670.
- ↑ Keck, A., Conradt, D., Mahler, A., Stolz, A., Mattes, R. and Klein, J. (2006). „Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6”. Microbiology 152: 1929-1940. PMID 16804169.
- ↑ Eaton, R.W. (1994). „Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid”. J. Bacteriol. 176: 7757-7762. PMID 8002605.
- ↑ Thompson, L.C., Ladner, J.E., Codreanu, S.G., Harp, J., Gilliland, G.L. and Armstrong, R.N. (2007). „2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida”. Biochemistry 46: 6710-6722. PMID 17508726.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.