TRNK (adenin58-N1)-metiltransferaza
(Preusmjereno sa stranice Gcd10p-Gcd14p)
tRNK (adenin58-N1)-metiltransferaza (EC 2.1.1.220, tRNK m1A58 metiltransferaza, tRNK (m1A58) metiltransferaza, TrmI, tRNK (m1A58) MTaza, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin58-N1)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| tRNK (adenin58-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.220 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + adenin58 u tRNK S-adenozil-L-homocistein + N1-metiladenin58 u tRNK
Ovaj enzim specifično metiluje adenin58 u tRNK. Metilacija A58 je kritična za održavanje stabilnosti inicijatora tRNKMet kod kvasca.
Reference uredi
- ↑ Droogmans, L., Roovers, M., Bujnicki, J.M., Tricot, C., Hartsch, T., Stalon, V. and Grosjean, H. (2003). „Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures”. Nucleic Acids Res. 31: 2148-2156. PMID 12682365.
- ↑ Varshney, U., Ramesh, V., Madabushi, A., Gaur, R., Subramanya, H.S. and RajBhandary, U.L. (2004). „Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase”. Nucleic Acids Res. 32: 1018-1027. PMID 14960715.
- ↑ Anderson, J., Phan, L. and Hinnebusch, A.G. (2000). „The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae”. Proc. Natl. Acad. Sci. USA 97: 5173-5178. PMID 10779558.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.