Formaldehid dismutaza
Formaldehid dismutaza (EC 1.2.99.4, aldehidna dismutaza, kanizanaza, nikotinoprotein aldehidna dismutaza) je enzim sa sistematskim imenom formaldehid:formaldehid oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Formaldehid dismutaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.99.4 | ||||||||
| CAS broj | 85204-94-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 formaldehid +H2O format + metanol
Ovaj enzim sadrži čvrsto nekovalentno vezani NADP(H) kofaktor, kao i Zn2+ i Mg2+. Enzim iz Mycobakterija sp. DSM 3803 takođe katalizuje reakciju enzima EC 1.1.99.36, NDMA-zavisne alkoholne dehidrogenaza i EC 1.1.99.37, NDMA-zavisne metanolne dehidrogenaza. Formaldehid and acetaldehid modu da deluju kao donori. Formaldehid, acetaldehid i propanal mogu da deluju kao akceptori.
Reference uredi
- ↑ Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C. (1983). „The dismutation of aldehydes by a bacterial enzyme”. Agric. Biol. Chem. 47: 39-46.
- ↑ Kato, N., Yamagami, T., Shimao, M. and Sakazawa, C. (1986). „Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61”. Eur. J. Biochem. 156: 59-64. PMID 3514215.
- ↑ Park, H., Lee, H., Ro, Y.T. and Kim, Y.M. (2010). „Identification and functional characterization of a gene for the methanol : N,N′-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)”. Microbiology 156: 463-471. PMID 19875438.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.