Fluorotreonin transaldolaza
Fluorotreonin transaldolaza (EC 2.2.1.8) je enzim sa sistematskim imenom fluoroacetaldehid:L-treonin aldehidtransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fluorotreonin transaldolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.8 | ||||||||
| CAS broj | 403503-13-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-treonin + fluoroacetaldehid acetaldehid + 4-fluoro-L-treonin
Ovaj enzim je piridoksal fosfatni protein. On takođe može da konvertuje hloroacetaldehid u 4-hloro-L-treonin.
Reference uredi
- ↑ Murphy, C.D., O'Hagan, D. and Schaffrath, C. (2001). „Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya”. Angew. Chem. Int. Ed. Engl. 40: 4479-4481. PMID 12404452.
- ↑ Murphy, C.D., Schaffrath, C. and O'Hagan, D. (2003). „Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya”. Chemosphere 52: 455-461. PMID 12738270.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.