Hinpirol je psihoaktivni lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni agonist D2 i D3 receptora.[4][5][6] Za hinpirol je pokazano da povećava lokomotornu aktivnost kod miševa. U jednoj studiji je nađeno da on indukuje kompulzivno ponašanje koje je simptomatično za opsesivno-kompulzivni poremećaj kod pacova.[7]
Hinpirol
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IUPAC ime
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(4aR,8aR)-5-propil-4,4a,5,6,7,8,8a,9-oktahidro-1H-pirazolo[3,4-g]hinolin |
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Identifikacija
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CAS registarski broj
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80373-22-4 Y
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PubChem[1][2]
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54562
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ChEMBL[3]
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CHEMBL240773 Y
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IUPHAR ligand
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2
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Jmol-3D slike
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Slika 1
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CCCN1CCC[C@H]2[C@H]1CC3=C(C2)NN=C3 |
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InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1 Y Kod: FTSUPYGMFAPCFZ-ZWNOBZJWSA-N Y |
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Svojstva
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Molekulska formula
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C13H21N3
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Molarna masa
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219.33 g mol−1
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Y (šta je ovo?)
(verifikuj)
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
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Infobox references
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Eilam D, Szechtman H (February 1989). „Biphasic effect of D-2 agonist quinpirole on locomotion and movements”. European Journal of Pharmacology 161 (2–3): 151–7. DOI:10.1016/0014-2999(89)90837-6. PMID 2566488.
- ↑ Navarro JF, Maldonado E (September 1999). „Behavioral profile of quinpirole in agonistic encounters between male mice”. Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. PMID 10544391.
- ↑ Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (October 2004). „Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats”. Neuropsychopharmacology 29 (10): 1823–30. DOI:10.1038/sj.npp.1300483. PMID 15138441.
- ↑ Szechtman Henry, Sulis William, Eilam David (1998). „Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)”. Behavioral Neuroscience 112 (6): 1475–85. DOI:10.1037/0735-7044.112.6.1475. PMID 9926830.
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