Terlipresin

Terlipresin
(IUPAC) ime
	1[(4R,7S,10S,13S,16S,19R)-19[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonylL-prolyl-N-(2-amino-2-oxoethyl)-L-lysinamide
Klinički podaci
Identifikatori
CAS broj	14636-12-5
ATC kod	H01BA04
PubChem	72081
DrugBank	EXPT03310
ChemSpider	65067
KEGG	D06672
Hemijski podaci
Formula	C52H74N16O15S2
Mol. masa	1227.37 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 ; Key: BENFXAYNYRLAIU-QSVFAHTRSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	~30%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	IV

Terlipresin je analog vazopresina koji se koristi kao vazoaktivni lek u tretmanima hipotenzije. Za njega je nađeno da je efektivan u slučajevima kad norepinefrin nije delotvoran. Terlipresin proizvodi kompanija New Medicon Pharma pod imenom Teripress. On je još dostupan kao Variquel (IS Pharmaceuticals) ili Glypressin (Ferring Pharmaceuticals).

Indikacije za koje se koristi su norepinefrin-otporni septički šok^[5] i hepatorenalni sindrom.^[6] Osim toga, on se koristi kod krvarenja varikoziteta jednjaka.^[7]

Vidi još uredi

Antidiuretik

Literatura uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ O'Brien A, Clapp L, Singer M (2002). „Terlipressin for norepinephrine-resistant septic shock”. Lancet 359 (9313): 1209–10. DOI:10.1016/S0140-6736(02)08225-9. PMID 11955542.
↑ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). „Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome”. J Hepatol 33 (1): 43–8. DOI:10.1016/S0168-8278(00)80158-0. PMID 10905585.
↑ Ioannou G, Doust J, Rockey D (2003). „Terlipressin for acute esophageal variceal hemorrhage”. Cochrane Database Syst Rev (1): CD002147. DOI:10.1002/14651858.CD002147. PMID 12535432.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[OBrien-5] O'Brien A, Clapp L, Singer M (2002). „Terlipressin for norepinephrine-resistant septic shock”. Lancet 359 (9313): 1209–10. DOI:10.1016/S0140-6736(02)08225-9. PMID 11955542.

[Uriz-6] Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). „Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome”. J Hepatol 33 (1): 43–8. DOI:10.1016/S0168-8278(00)80158-0. PMID 10905585.

[Ioannou-7] Ioannou G, Doust J, Rockey D (2003). „Terlipressin for acute esophageal variceal hemorrhage”. Cochrane Database Syst Rev (1): CD002147. DOI:10.1002/14651858.CD002147. PMID 12535432.

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