Dopastin

Dopastin
Naziv po klasifikaciji	(2E)-N(2S)-2-[Hidroksi(nitrozo)amino]-3-metilbutil2-butenamid
Identifikacija
CAS registarski broj	37134-80-8
PubChem	6434226
ChemSpider	4939169
Jmol-3D slike	Slika 1
SMILES
	O=C(NC[C@@H](N(O)N=O)C(C)C)/C=C/C
InChI
	InChI=1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 ; Kod: FJUBKTNNXRFHFD-WTSVBCDHSA-N InChI=1/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1; Kod: FJUBKTNNXRFHFD-WTSVBCDHBR
Svojstva
Molekulska formula	C9H17N3O3
Molarna masa	215.25 g mol−1
Tačka topljenja	116-119 °C
pKa	5,1
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Dopastin je hemijsko jedinjenje koje formira bakterija Pseudomonas No. BAC-125.^[5] Ono je prvi put izolovano i okarakterisano 1972. Dopastin deluje kao inhibitor enzima dopaminska β-hidroksilaza.^[6]

Dopastin se može sintetički pripremiti iz L-valinola.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th izd.). Merck Publishing. 1989. ISBN 0-911910-28-X. , pages+3417
↑ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). „Dopastin, an inhibitor of dopamine -hydroxylase”. The Journal of antibiotics 25 (8): 497–500. PMID 4648494.
↑ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). „Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase”. Agric. Biol. Chem. 38 (11): 2107–2111. DOI:10.1271/bbb1961.38.2107.
↑ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). „Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin”. Journal of the Chemical Society, Chemical Communications (4): 147. DOI:10.1039/C39730000147.

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[Merck-4] 4,0 ^4,1 The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th izd.). Merck Publishing. 1989. ISBN 0-911910-28-X. , pages+3417

[5] Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). „Dopastin, an inhibitor of dopamine -hydroxylase”. The Journal of antibiotics 25 (8): 497–500. PMID 4648494.

[6] H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). „Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase”. Agric. Biol. Chem. 38 (11): 2107–2111. DOI:10.1271/bbb1961.38.2107.

[7] Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). „Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin”. Journal of the Chemical Society, Chemical Communications (4): 147. DOI:10.1039/C39730000147.

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