Rubredoksin—NAD+ reduktaza
(Preusmjereno sa stranice DPNH-rubredoxin reductase)
Rubredoksin—NAD+ reduktaza (EC 1.18.1.1, rubredoksinska reduktaza, rubredoksin-nikotinamid adenin dinukleotidna reduktaza, dihidronikotinamid adenin dinukleotid-rubredoksinska reduktaza, redukovani nikotinamid adenin dinukleotid-rubredoksinska reduktaza, NADH-rubredoksinska reduktaza, rubredoksin-NAD reduktaza, NADH: rubredoksinska oksidoreduktaza, DPNH-rubredoksinska reduktaza, NADH-rubredoksinska oksidoreduktaza) je enzim sa sistematskim imenom rubredoksin:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Rubredoksin—NAD+ reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.18.1.1 | ||||||||
| CAS broj | 9032-27-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 redukovani rubredoksin + NAD+ + H+ 2 oksidovani rubredoksin + NADH
Za rad ovog enzima je neophodan FAD. Enzim iz Clostridium acetobutilicum redukuje rubredoksin, fericijanid i dihlorofenolindofenol.
Reference uredi
- ↑ Peterson, J.A., Kusunose, M., Kusunose, E. and Coon, M.J. (1967). „Enzymatic ω-oxidation. II. Function of rubredoxin as the electron carrier in ω-hydroxylation”. J. Biol. Chem. 242: 4334-4340. PMID 4294330.
- ↑ Ueda, T., Lode, E.T. and Coon, M.J. (1972). „Enzymatic ω-oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase”. J. Biol. Chem. 247: 2109-2116. PMID 4335861.
- ↑ Ueda, T., Lode, E.T. and Coon, M.J. (1972). „Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation”. J. Biol. Chem. 247: 5010-5016. PMID 4403503.
- ↑ Petitdemange, H., Marczak, R., Blusson, H. and Gay, R. (1979). „Isolation and properties of reduced nicotinamide adenine dinucleotide rubredoxin oxidoreductase of Clostridium acetobutylicum”. Biochem. Biophys. Res. Commun. 91: 1258-1265. PMID 526302.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.