6-Dezoksi-5-ketofruktoza 1-fosfat sintaza
(Preusmjereno sa stranice DKFP sintaza)
6-Dezoksi-5-ketofruktoza 1-fosfat sintaza (EC 2.2.1.11, DKFP sintaza, MJ1585 (gen)) je enzim sa sistematskim imenom 2-oksopropanal:D-fruktoza 1,6-bisfosfat gliceron-fosfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6-Dezoksi-5-ketofruktoza 1-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.11 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) metilglioksal + D-fruktoza 1,6-bisfosfat D-gliceraldehid 3-fosfat + 1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat
- (2) metilglioksal + D-fruktoza 1-fosfat D-gliceraldehid + 1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat
Ovaj enzim učestvujue u alternativnoj biosintezi 3-dehidrohinata (DHQ), koji učestvuje u kanoničkoj biosintezi aromatičnnih aminokiselina.
Reference uredi
- ↑ White, R.H. and Xu, H. (2006). „Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii”. Biochemistry 45: 12366-12379. PMID 17014089.
- ↑ Samland, A.K., Wang, M. and Sprenger, G.A. (2008). „MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity”. FEMS Microbiol. Lett. 281: 36-41. PMID 18318840.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.