CY-208243
(Preusmjereno sa stranice CY-208,243)
CY-208,243 je lek koji deluje kao selektivni dopaminski agonist za D1 podtipe. Za razliku od većene D1-selektivnih agonista, on je pokazao efikasnot u životinjskim modelima za Parkinsonovu bolest.[3][4][5][6][7]
(IUPAC) ime | |||
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4,6,6a,7,8,12b-heksahidro-7-metilindolo(4,3-ab)-fenantridin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 100999-26-6 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 58144 | ||
Hemijski podaci | |||
Formula | C19H18N2 | ||
Mol. masa | 274,359 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). „Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors”. Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064.
- ↑ Beninger RJ, Rolfe NG (December 1995). „Dopamine D1-like receptor agonists impair responding for conditioned reward in rats”. Behavioural Pharmacology 6 (8): 785–793. PMID 11224381.
- ↑ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). „Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys”. Advances in Neurology 69: 239–44. PMID 8615134.
- ↑ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). „Dopamine D1 receptor agonists induce penile erections in rats”. European Journal of Pharmacology 460 (1): 71–4. DOI:10.1016/S0014-2999(02)02881-9. PMID 12535862.
- ↑ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). „Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243”. Behavioural Brain Research 156 (2): 173–9. DOI:10.1016/j.bbr.2004.05.019. PMID 15582103.