6-Karboksitetrahidropterinska sintaza
(Preusmjereno sa stranice CPH4 sintaza)
6-Karboksitetrahidropterinska sintaza (EC 4.1.2.50, CPH4 sintaza, queD (gen), ToyB, ykvK (gen)) je enzim sa sistematskim imenom 7,8-dihidroneopterin 3'-trifosfat acetaldehid-lijaza (6-karboksi-5,6,7,8-tetrahidropterin and formira trifosfat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6-Karboksitetrahidropterinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| 6-Karboksitetrahidropterinska sintaza hexamer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.2.50 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 7,8-dihidroneopterin 3'-trifosfat + H2O 6-karboksi-5,6,7,8-tetrahidropterin + acetaldehid + trifosfat
Ovaj enzim vezuje Zn2+.
Reference uredi
- ↑ Cicmil, N. and Shi, L. (2008). „Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 119-122. PMID 18259064.
- ↑ McCarty, R.M., Somogyi, A. and Bandarian, V. (2009). „Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase”. Biochemistry 48: 2301-2303. PMID 19231875.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.