Izamoltan
(Preusmjereno sa stranice CGP-361A)
Izamoltan (CGP-361A) je lek koji se koristi u naučnim istraživanjima. On deluje kao antagonist β-adrenergičkog, 5-HT1A, i 5-HT1B receptora. On je oko pet puta potentniji na 5-HT1B receptoru (21 nmol/l) u odnosu na 5-HT1A receptor (112 nmol/l).[4] On ima anksiolitičko dejstvo na glodarima.[5]
(IUPAC) ime | |||
---|---|---|---|
1-(propan-2-ilamino)-3-(2-pirol-1-ilfenoksi)propan-2-ol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 99740-06-4 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 127403 | ||
ChemSpider[3] | 113051 | ||
Hemijski podaci | |||
Formula | C16H22N2O2 | ||
Mol. masa | 274,357 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. (1991). „Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.”. Naunyn Schmiedebergs Arch Pharmacol. 343 (1): 1–6. PMID 1674359.
- ↑ Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. (1988). „Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.”. Naunyn Schmiedebergs Arch Pharmacol. 337 (6): 609–620. PMID 2905765.