CDP-paratoza sintaza
(Preusmjereno sa stranice CDP-paratozna sintaza)
CDP-paratoza sintaza (EC 1.1.1.342, rfbS (gen)) je enzim sa sistematskim imenom CDP-alfa-D-paratoza:NADP+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| CDP-paratoza sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.342 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- CDP-alfa-D-paratoza + NADP+ CDP-4-dehidro-3,6-didezoksi-alfa-D-glukoza + NADPH + H+
Ovaj enzim učestvuje u sintezi paratoza i tiveloza, obično 3,6-didezoksiheksoznih šećera koji formiraju deo O-antigen u lipopolisaharidima nekoliko enteričkih bakterija. Izolovan je iz Salmonella enterica.
Reference uredi
- ↑ Verma, N. and Reeves, P. (1989). „Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae”. J. Bacteriol. 171: 5694-5701. PMID 2793833.
- ↑ Hallis, T.M., Lei, Y., Que, N.L. and Liu, H. (1998). „Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase”. Biochemistry 37: 4935-4945. PMID 9538012.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.